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In situ detection of warfarin using time-correlated single-photon counting
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2011 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 407, no 1, 60-62 p.Article in journal (Refereed) Published
Abstract [en]

Here we report on a novel method for the direct in situ measurement of specific isomeric forms of the anticoagulant warfarin using time correlated single-photon counting (TCSPC) spectroscopy in conjunction with synthetic Sudlow I binding site receptors. The method is highly robust over the clinically significant concentration range, and demonstrates the potential of the binding site mimics in conjunction with the spectroscopic strategy employed here for the determination of this important pharmaceutical in clinical or even environmental samples.

Place, publisher, year, edition, pages
2011. Vol. 407, no 1, 60-62 p.
Keyword [en]
Warfarin, Time resolved fluorescence spectroscopy, Time correlated single photon counting, Human serum albumin, Sudlow I, Molecularly imprinted polymer, MIP
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:uu:diva-152920DOI: 10.1016/j.bbrc.2011.02.103ISI: 000289541900012PubMedID: 21354105OAI: oai:DiVA.org:uu-152920DiVA: diva2:414416
Available from: 2011-05-03 Created: 2011-05-03 Last updated: 2017-12-11Bibliographically approved

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