uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
In situ detection of warfarin using time-correlated single-photon counting
Show others and affiliations
2011 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 407, no 1, 60-62 p.Article in journal (Refereed) Published
Abstract [en]

Here we report on a novel method for the direct in situ measurement of specific isomeric forms of the anticoagulant warfarin using time correlated single-photon counting (TCSPC) spectroscopy in conjunction with synthetic Sudlow I binding site receptors. The method is highly robust over the clinically significant concentration range, and demonstrates the potential of the binding site mimics in conjunction with the spectroscopic strategy employed here for the determination of this important pharmaceutical in clinical or even environmental samples.

Place, publisher, year, edition, pages
2011. Vol. 407, no 1, 60-62 p.
Keyword [en]
Warfarin, Time resolved fluorescence spectroscopy, Time correlated single photon counting, Human serum albumin, Sudlow I, Molecularly imprinted polymer, MIP
National Category
Biochemistry and Molecular Biology
URN: urn:nbn:se:uu:diva-152920DOI: 10.1016/j.bbrc.2011.02.103ISI: 000289541900012PubMedID: 21354105OAI: oai:DiVA.org:uu-152920DiVA: diva2:414416
Available from: 2011-05-03 Created: 2011-05-03 Last updated: 2011-05-03Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
By organisation
Department of Biochemistry and Organic Chemistry
In the same journal
Biochemical and Biophysical Research Communications - BBRC
Biochemistry and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 164 hits
ReferencesLink to record
Permanent link

Direct link