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Single-fiber conduction velocity test allows earlier detection of abnormalities in diabetes
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Clinical Neurophysiology.
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2011 (English)In: Muscle and Nerve, ISSN 0148-639X, E-ISSN 1097-4598, Vol. 43, no 5, 652-656 p.Article in journal (Refereed) Published
Abstract [en]

Introduction: The purpose of this study was to determine whether single-fiber conduction velocity (SF-CV) of a small number of axons increases sensitivity for identification of motor nerve conduction alterations in patients with diabetes. Methods: Twenty-one consecutive diabetic patients in good metabolic control were studied. For each patient, conventional (C-CV) and SF-CV results were correlated with the presence of neuropathic symptoms. Results: Nine of 21 patients reported symptoms suggestive of mild nerve impairment. Three patients had abnormal sural nerve CV, 1 of whom also had abnormal motor nerve conduction. Eighteen patients had normal findings on conventional tests, 3 of whom had slowing of SF-CV. Conclusions: SF-CV is able to detect mild myelin damage with higher sensitivity than conventional tests. The use of SF-CV may be a helpful tool in the early identification of diabetic polyneuropathy, and it may be useful for tailoring an approach to diabetic polyneuropathy.

Place, publisher, year, edition, pages
2011. Vol. 43, no 5, 652-656 p.
Keyword [en]
diabetes, diabetic polyneuropathy, electrodiagnosis, neurophysiology, SFEMG, single-fiber conduction velocity
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-152831DOI: 10.1002/mus.21935ISI: 000289420500006OAI: oai:DiVA.org:uu-152831DiVA: diva2:414557
Available from: 2011-05-03 Created: 2011-05-02 Last updated: 2011-05-03Bibliographically approved

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