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Dysprosium-enhanced MR imaging for tumor tissue characterization: an experimental study in a human xenograft model
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology.
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1997 (English)In: Acta Radiologica, ISSN 0284-1851, E-ISSN 1600-0455, Vol. 38, no 2, 281-286 p.Article in journal (Refereed) Published
Abstract [en]

PURPOSE:

To evaluate dysprosium-enhanced MR imaging for differentiation between morphologically intact and necrotic tumor tissue in a tumor model.

MATERIAL AND METHODS:

A human colon carcinoma was transplanted subcutaneously into 9 nude (immunodeprived) rats. MR imaging was performed before and after injection of the dysprosium agent Dy-DTPA-BMA. T1-, T2- and T2*-weighted sequences were acquired. The tumors were dissected, histological sections were prepared, and compared with corresponding MR images.

RESULTS:

In intact tissue, the MR signal intensity in the T2- and T2*-weighted images decreased after Dy injection and the delineation of the intact regions were sharp and corresponded well to the gross histological sections.

CONCLUSION:

Dy-enhanced MR imaging facilitated the differentiation between intact and necrotic tumor tissue.

Place, publisher, year, edition, pages
1997. Vol. 38, no 2, 281-286 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-152965PubMedID: 9093166OAI: oai:DiVA.org:uu-152965DiVA: diva2:414771
Available from: 2011-05-04 Created: 2011-05-04 Last updated: 2017-12-11Bibliographically approved

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