Dysprosium-enhanced MR imaging for tumor tissue characterization: an experimental study in a human xenograft model
1997 (English)In: Acta Radiologica, ISSN 0284-1851, E-ISSN 1600-0455, Vol. 38, no 2, 281-286 p.Article in journal (Refereed) Published
To evaluate dysprosium-enhanced MR imaging for differentiation between morphologically intact and necrotic tumor tissue in a tumor model.
MATERIAL AND METHODS:
A human colon carcinoma was transplanted subcutaneously into 9 nude (immunodeprived) rats. MR imaging was performed before and after injection of the dysprosium agent Dy-DTPA-BMA. T1-, T2- and T2*-weighted sequences were acquired. The tumors were dissected, histological sections were prepared, and compared with corresponding MR images.
In intact tissue, the MR signal intensity in the T2- and T2*-weighted images decreased after Dy injection and the delineation of the intact regions were sharp and corresponded well to the gross histological sections.
Dy-enhanced MR imaging facilitated the differentiation between intact and necrotic tumor tissue.
Place, publisher, year, edition, pages
1997. Vol. 38, no 2, 281-286 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-152965PubMedID: 9093166OAI: oai:DiVA.org:uu-152965DiVA: diva2:414771