Positron emission tomography with 11C-D-deprenyl in patients with rheumatoid arthritis. Evaluation of knee joint inflammation before and after intra-articular glucocorticoid treatment
1997 (English)In: Scandinavian Journal of Rheumatology, ISSN 0300-9742, Vol. 26, no 1, 43-48 p.Article in journal (Refereed) Published
Seven patients with arthritic disease and with clinical signs of inflammation of the knee joint, were investigated with positron emission tomography (PET) after injection of [N-methyl-11C]-D-deprenyl. Two healthy volunteers were included as controls. In five patients the investigation was repeated after an intra-articular injection of glucocorticoids. All patients showed very high uptake of the tracer in the paraarticular structures of the joint. After treatment there was approximately a 50% reduction of the uptake in the treated knees, both in the high uptake regions and in the surrounding soft tissues. No change was observed in the non-treated knees. In the healthy volunteers, only soft tissue surrounding the joint showed an uptake of the tracer, but at a magnitude which was 6-8 times lower than the high uptake regions in the arthritis patients. Although the mechanisms for the high uptake of 11C-D-deprenyl in affected joints of patients with arthritis is not clear, the present work points to a potential of PET for the assessment of disease intensity and monitoring of treatment.
Place, publisher, year, edition, pages
1997. Vol. 26, no 1, 43-48 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-152966PubMedID: 9057801OAI: oai:DiVA.org:uu-152966DiVA: diva2:414772