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Pharmacokinetics and experimental PET imaging of a bromine-76-labeled monoclonal anti-CEA antibody
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Radiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Biomedical Radiation Sciences.
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1997 (English)In: Journal of Nuclear Medicine, ISSN 0161-5505, E-ISSN 1535-5667, Vol. 38, no 3, p. 395-401Article in journal (Refereed) Published
Abstract [en]

Bromine-76 is potentially useful as a radiolabel for monoclonal antibodies (MAbs) in PET imaging. The purpose of the present study was to evaluate the 76Br-labeled anticarcinoembryonic antigen (-CEA) MAb 38S1 as a tumor imaging agent in an experimental tumor model and to study the pharmacokinetics of 76Br-38S1 in comparison with 125I-38S1.

METHODS:

Nude rats carrying human colon carcinoma xenografts were co-injected with directly labeled 76Br-38S1 and 125I-38S1. Biodistribution of labeled 38S1 was monitored for 4 days after administration, in the case of 76Br activity, including PET imaging. In addition, catabolism of radiolabeled MAbs was analyzed by gel filtration chromatography of blood plasma and homogenized tissues.

RESULTS:

Tumor sites could be readily identified by PET imaging from 46 hr after administration of 76Br-38S1 and onwards. The concentration of 76Br activity in tumors, blood and most normal tissues was higher than the corresponding 125I concentration at all time points. This was mainly due to catabolism of radiolabeled MAb, resulting in free radiohalides, of which 76Br- was retained in contrast to the rapidly excreted 125I- ion.

CONCLUSION:

Bromine-76-labeled anti-CEA MAbs may be applied for experimental tumor imaging with PET.

Place, publisher, year, edition, pages
1997. Vol. 38, no 3, p. 395-401
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-152967PubMedID: 9074527OAI: oai:DiVA.org:uu-152967DiVA, id: diva2:414773
Available from: 2011-05-04 Created: 2011-05-04 Last updated: 2017-12-11Bibliographically approved

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