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Beta-amyloid deposition in brains of subjects with diabetes
Department of Neuroscience and Neurology, University of Kuopio Finland .
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2009 (English)In: Neuropathology and Applied Neurobiology, ISSN 0305-1846, E-ISSN 1365-2990, Vol. 35, no 1, 60-68 p.Article in journal (Refereed) Published
Abstract [en]


A causative association between diabetes mellitus (DM) and Alzheimer's disease (AD) has been suggested based on clinical and epidemiological studies. One hypothesis is that the link between DM and AD is related to the function of insulin-degrading enzyme (IDE), an enzyme that degrades not only insulin and pancreatic amylin but also beta-amyloid (Abeta). Thus, in diabetics, insulin and Abeta might compete for IDE and this might lead to an increase in Abeta. The objective of this study was to test the hypothesis that hyperinsulinaemia can elevate Abeta levels and thus contribute to AD pathology in humans.


Neuropathological examination was carried out employing conventional and immunohistochemical (IHC) methods of the brains obtained post mortem from 701 aged subjects.


The loads of IHC/Abeta, silver stained neuritic plaques (NP) and neurofibrillary tangles (NFT) were significantly higher in subjects carrying the Apolipoprotein E e4 allele. In contrast, the loads of Abeta, NPs and NFT in the brains were not influenced by hyperglycaemia when comparing 134 diabetic with 567 non-diabetic subjects.


We conclude that the hypothesis that hyperinsulinaemia would significantly elevate the Abeta load and thus increase the extent of AD pathology cannot be supported. Our result challenges the claim that DM is a direct risk factor of developing AD. Thus further studies on pathological lesions in demented diabetics should be conducted.

Place, publisher, year, edition, pages
2009. Vol. 35, no 1, 60-68 p.
National Category
Neurology Cell and Molecular Biology
Research subject
Neurology; Pathology
URN: urn:nbn:se:uu:diva-153118DOI: 10.1111/j.1365-2990.2008.00948.xPubMedID: 18346114OAI: oai:DiVA.org:uu-153118DiVA: diva2:415253
Available from: 2011-05-06 Created: 2011-05-06 Last updated: 2016-05-13

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