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IL-10 is up regulated in early and transitional stages in vervet monkeys experimentally infected with Trypanosoma brueei rhodesiense
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Comparative Medicine.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Comparative Medicine.
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2006 (English)In: Parasitology international, ISSN 1383-5769, Vol. 55, no 4, 243-248 p.Article in journal (Refereed) Published
Abstract [en]

IL-10 has been suggested as a possible parameter for human African trypanosomiasis stage determination. However, conclusive experimental studies have not been carried out to evaluate this, which is a prerequisite before a potential test can be validated in humans for diagnostic purposes. We used the vervet monkey model of trypanosomiasis to scrutinize IL-10 in blood and cerebrospinal fluid (CSF). Five adult males were experimentally infected with T.b. rhodesiense. The infected animals became anemic and exhibited weight loss. Parasitemia was patent after 3 days and fluctuated around 3.7 x 10(7) trypanosomes/ml throughout the experimental period. The total CSF white cell counts increased from pre-infection means around 3 cells/mu l to a peak of 30 cells/mu l, 42 days post-infection (DPI). IL-10 was not detectable (< 2 pg/ml) in serum prior to infection. IL-10 serum concentrations increased to 273 pg/ml 10 DPI coinciding with the first peak of parasitemia. Thereafter the levels declined to a mean value of 77 pg/ml 34 DPI followed by a significant rise to a second peak of 304 pg/ml (p < 0.008) 42 DPI. There was no detectable IL-10 in CSF. IL-10 synthesis is thus stimulated both in the early and transitional stages of experimental trypanosomiasis. That IL-10 is produced in early stage disease is an interesting finding unlikely to be detected in humans where it is difficult to determine the exact time of infection. The IL-10 peak observed on day 42 of infection might indicate onset of parasite neuroinvasion coinciding with a peak in white blood cell counts in the blood and CSF.

Place, publisher, year, edition, pages
2006. Vol. 55, no 4, 243-248 p.
Keyword [en]
Trypanosoma brucei rhodesiense, Chlorocebus aethiops, Cereopithecus aethiops, vervet monkey, African green monkey, human African trypanosomiasis, sleeping sickness, IL-10, diagnosis
National Category
Biological Sciences
URN: urn:nbn:se:uu:diva-153160DOI: 10.1016/j.parint.2006.06.004ISI: 000242510100002PubMedID: 16901747OAI: oai:DiVA.org:uu-153160DiVA: diva2:415407
Available from: 2011-05-06 Created: 2011-05-06 Last updated: 2011-05-06Bibliographically approved

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