uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Seizures and the Natural History of World Health Organization Grade II Gliomas: A Review
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neurology.
2011 (English)In: Neurosurgery, ISSN 0148-396X, E-ISSN 1524-4040, Vol. 68, no 5, 1326-1333 p.Article, review/survey (Refereed) Published
Abstract [en]


The majority of adults with low-grade gliomas have seizures. Despite the frequency of seizures as initial symptoms and symptoms of later disease, seizures in relation to the natural course of low-grade gliomas have received little attention.


In this review, we provide an update of the literature on the prognostic impact of preoperative seizures and discuss the tumor-and treatment-related factors affecting seizure control at later stages of the disease.


Seizures occur most frequently at disease presentation and predict a more favorable outcome. Initial seizures are correlated with tumor location and possibly indirectly to the molecular profile of the tumor. About 50% of all patients with seizures at presentation continue to have seizures before surgery. Maximal tumor resection, including resection of epileptic foci, is a valuable strategy for improving seizure control. In addition, radiotherapy and chemotherapy, as single therapies or in combination with surgery, have shown beneficial effects in terms of seizure reduction. Recurrent seizures after macroscopically complete tumor resection may be a marker for accelerated tumor growth. Recurrent seizures after an initial transient stabilization after radiotherapy and/or chemotherapy may be a marker for anaplastic tumor transformation.


Preoperative seizures likely reflect, apart from tumor location, intrinsic tumor properties as well. Change in seizure control in individual patients is frequently associated with altered tumor behavior. Including seizures and seizure control as clinical parameters is recommended in future trials of low-grade gliomas to further establish the prognostic value of these symptoms and to identify the factors affecting seizure control.

Place, publisher, year, edition, pages
2011. Vol. 68, no 5, 1326-1333 p.
Keyword [en]
Epilepsy, Low-grade glioma, Survival, Tumor progression
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-153233DOI: 10.1227/NEU.0b013e31820c3419ISI: 000289230300059OAI: oai:DiVA.org:uu-153233DiVA: diva2:415706
Available from: 2011-05-09 Created: 2011-05-09 Last updated: 2014-03-20Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Smits, Anja
By organisation
In the same journal
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 292 hits
ReferencesLink to record
Permanent link

Direct link