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An experimental model of myocardial and cerebral global ischemia and reperfusion
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Oxidative Stress and Inflammation.
2011 (English)In: Studies on experimental models, Totowa, NJ: Springer Science+Business Media B.V., 2011, 279-302 p.Chapter in book (Refereed)
Abstract [en]

Despite many programs aimed at better immediate care of cardiac arrest victims, the subsequent mortality rate remains high, with myocardial and central nervous system injuries as the most common causes of death. Preclinical research is badly needed to produce a sound base for future clinical trials and possible improvements in clinical outcome. Our continued use of a porcine model for studies of cerebral effects of anoxia and reperfusion has shown that this model results in standardized effects, where time of cardiac arrest and reperfusion are approximately proportional to the ischemic neurological injury. Free radical damage is proved to be an important pathophysiological mechanism in the early development of this nervous injury. Hence, not unexpectedly, early experimental treatment after total ischemia during early reperfusion results in improved measures of cerebral tissue damage.

Place, publisher, year, edition, pages
Totowa, NJ: Springer Science+Business Media B.V., 2011. 279-302 p.
Series
Oxidative Stress in Applied Basic Research and Clinical Practice
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-153247DOI: 10.1007/978-1-60761-956-7_13ISBN: 978-1-60761-955-0 (print)ISBN: 1607619555 (print)ISBN: 9781607619567 (print)ISBN: 1607619563 (print)OAI: oai:DiVA.org:uu-153247DiVA: diva2:415707
Available from: 2011-05-09 Created: 2011-05-09 Last updated: 2012-05-22Bibliographically approved

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Wiklund, Lars

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