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Association of cytochrome P450 1B1 polymorphism with first-trimester miscarriage
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Pharmacology.
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2006 (English)In: Fertility and Sterility, ISSN 0015-0282, Vol. 86, no 5, 1498-1503 p.Article in journal (Refereed) Published
Abstract [en]
Objective: To determine whether the cytochrome P450 1B1 (CYP1B1) Val432Leu polymorphism and caffeine intake. Design: The population-based case-control study included 507 women with miscarriage in the first trimester of pregnancy and 908 controls with a normal first trimester pregnancy. The controls were frequently matched to cases. The material was analyzed taking maternal age, smoking habits, alcohol intake, caffeine intake, fetal karyotype, nausea, and vomiting into consideration. Setting: University hospital and primary care facility. Main Outcome Measure(s): CYP1B1 Val432Leu genotype frequencies in cases and controls. Result(s): Carriers of the CYP1B1 432 Val/Val genotype were at a higher risk of miscarriage in the first trimester of pregnancy (odds ratio = 1.46; 95% confidence interval 1.02-2.08). We also found a significant interaction between genotype and caffeine intake. Conclusion(s): CYP1B1 Val432Leu polymorphism is associated with first-trimester miscarriage, and it may also modify the risk among coffee drinkers.
Place, publisher, year, edition, pages
2006. Vol. 86, no 5, 1498-1503 p.
Keyword [en]
misscarriage, cytochrome P450, CYP1B1, polymorphism, caffeine, androgen metabolism, estradiol
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-153403DOI: 10.1016/j.fertnstert.2006.03.059ISI: 000241804100036PubMedID: 16978616OAI: oai:DiVA.org:uu-153403DiVA: diva2:416688
Available from: 2011-05-12 Created: 2011-05-12 Last updated: 2011-05-12Bibliographically approved

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