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SNP typing using Molecular Inversion Probes
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medicinsk genetik och genomik.
2008 (English)In: Forensic Science International: Genetics Supplement Series, ISSN 1875-1768, E-ISSN 1875-175X, Vol. 1, no 12, 473-475 p.Article in journal (Refereed) Published
Abstract [en]

Single nucleotide polymorphism (SNP) typing will be useful in forensic analysis but is limited by the multiplexing capacity of multiple targets in the PCR. A strategy to circumvent this problem can be to use molecular inversion probes (MIPs). MIPs are linear oligonucleotides 70–100 nt in length, with end-segments that are complementary to a target sequence. In this study, 10 SNPs were selected for SNP detection performed by pyrosequencing. The high-multiplexing capacity of MIPs makes this technology very useful for large scale SNP genotyping, but may also be useful for DNA typing in forensic investigations.

Place, publisher, year, edition, pages
2008. Vol. 1, no 12, 473-475 p.
Keyword [en]
Padlock probes, Molecular inversion probes, SNPs, Genotyping, Universal primers
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-153476OAI: oai:DiVA.org:uu-153476DiVA: diva2:416935
Available from: 2011-05-13 Created: 2011-05-13 Last updated: 2017-12-11

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