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Free form fabricated features on CoCr implants with and without hydroxyapatite coating in vivo: a comparative study of bone contact and bone growth induction
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences.
Dept of Biomaterials, Sahlgrenska Academy, University of Gothenburg, Göteborg.
Teknimed S.A., Vic en Bigorre, Frankrike.
Finsbury Development Ltd, Leatherhead, UK.
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2011 (English)In: Journal of materials science. Materials in medicine, ISSN 0957-4530, E-ISSN 1573-4838, Vol. 22, no 4, 899-906 p.Article in journal (Refereed) Published
Abstract [en]

The current study evaluates the in vivo response to free form fabricated cobalt chromium (CoCr) implants with and without hydroxyapatite (HA) plasma sprayed coatings. The free form fabrication method allowed for integration of complicated pyramidal surface structures on the cylindrical implant. Implants were press fit into the tibial metaphysis of nine New Zealand white rabbits. Animals were sacrificed and implants were removed and embedded. Histological analysis, histomorphometry and electron microscopy studies were performed. Focused ion beam was used to prepare thin sections for high-resolution transmission electron microscopy examination. The fabricated features allowed for effective bone in-growth and firm fixation after 6 weeks. Transmission electron microscopy investigations revealed intimate bone-implant integration at the nanometre scale for the HA coated samples. In addition, histomorphometry revealed a significantly higher bone contact on HA coated implants compared to native CoCr implants. It is concluded that free form fabrication in combination with HA coating improves the early fixation in bone under experimental conditions.

Place, publisher, year, edition, pages
2011. Vol. 22, no 4, 899-906 p.
National Category
Medical and Health Sciences Engineering and Technology
Research subject
Engineering Science with specialization in Materials Science
URN: urn:nbn:se:uu:diva-153574DOI: 10.1007/s10856-011-4253-3ISI: 000290044000016PubMedID: 21305340OAI: oai:DiVA.org:uu-153574DiVA: diva2:417176
Available from: 2011-05-16 Created: 2011-05-16 Last updated: 2016-04-20Bibliographically approved

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