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Kcnq1ot1: A chromatin regulatory RNA
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Genomics. (Kanduri)
2011 (English)In: Seminars in Cell and Developmental Biology, ISSN 1084-9521, E-ISSN 1096-3634, Vol. 22, no 4, 343-350 p.Article, review/survey (Refereed) Published
Abstract [en]

There is a growing interest for noncoding RNA (ncRNA)-mediated epigenetic regulation of transcription in diverse biological functions. Recent evidence suggests that a subset of long ncRNA epigenetically regulate the transcription of multiple genes in chromosomal domains via interaction with chromatin. Kcnq1ot1 is one such long chromatin-interacting ncRNA that silences multiple genes in the Kcnq1 domain by establishing a repressive higher order chromatin structure. This is done by the recruitment of chromatin and DNA-modifying proteins. This review looks at recent evidence supporting the notion that Kcnq1ot1-mediated silencing is a multilayered pathway. Comparing the mode of action of Kcnq1ot1 with other well-investigated chromatin regulatory long ncRNAs, such as Xist, HOTAIR and Airn, revealed that chromatin regulatory ncRNAs share common epigenetic pathways in the silencing of multiple genes.

Place, publisher, year, edition, pages
2011. Vol. 22, no 4, 343-350 p.
Keyword [en]
Chromatin, Noncoding RNA, Epigenetics, Heterochromatin Kcnq1ot1, Genomic imprinting, Polycomb proteins, X-chromosome inactivation, Xist, Airn
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-153623DOI: 10.1016/j.semcdb.2011.02.020ISI: 000295212900004PubMedID: 21345374OAI: oai:DiVA.org:uu-153623DiVA: diva2:417312
Swedish Research Council
Available from: 2011-05-16 Created: 2011-05-16 Last updated: 2011-10-19Bibliographically approved

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