uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Towards a synthetic avidin mimic
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry.
2011 (English)In: Analytical and Bioanalytical Chemistry, ISSN 1618-2642, E-ISSN 1618-2650, Vol. 400, no 5, 1397-1404 p.Article in journal (Refereed) Published
Abstract [en]

A series of streptavidin-mimicking molecularly imprinted polymers has been developed and evaluated for their biotin binding characteristics. A combination of molecular dynamics and NMR spectroscopy was used to examine potential polymer systems, in particular with the functional monomers methacrylic acid and 2-acrylamidopyridine. The synthesis of copolymers of ethylene dimethacrylate and one or both of these functional monomers was performed. A combination of radioligand binding studies and surface area analyses demonstrated the presence of selectivity in polymers prepared using methacrylic acid as the functional monomer. This was predicted by the molecular dynamics studies showing the power of this methodology as a prognostic tool for predicting the behavior of molecularly imprinted polymers.

Place, publisher, year, edition, pages
2011. Vol. 400, no 5, 1397-1404 p.
Keyword [en]
Molecularly imprinted polymer, Molecular dynamics, Receptor mimic, Biotin
National Category
Chemical Sciences
URN: urn:nbn:se:uu:diva-153653DOI: 10.1007/s00216-011-4907-5ISI: 000289792400020PubMedID: 21442363OAI: oai:DiVA.org:uu-153653DiVA: diva2:417381
Available from: 2011-05-17 Created: 2011-05-17 Last updated: 2011-05-17Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
By organisation
Department of Biochemistry and Organic Chemistry
In the same journal
Analytical and Bioanalytical Chemistry
Chemical Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 157 hits
ReferencesLink to record
Permanent link

Direct link