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Pathophysiology and Pharmacological Targeting of Tumor-Induced Bone Disease: Current Status and Emerging Therapeutic Interventions
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
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2011 (English)In: Current Medicinal Chemistry, ISSN 0929-8673, Vol. 18, no 11, 1584-1598 p.Article, review/survey (Refereed) Published
Abstract [en]

Bone disease is a common complication of metastatic solid tumors but also of primary hematological malignancies such as multiple myeloma. Our understanding of the molecular mechanisms underlying the development of bone disease by solid tumors and multiple myeloma has been significantly improved. A complex inter-dependence exists between bone disease and malignant cell growth, creating a vicious cycle of extensive bone destruction and tumor progression. Although myeloma and solid tumors share a number of common molecular pathogenetic mechanisms, they involve distinct pathophysiological pathways, resulting in osteoclastic bone resorption and inhibition of bone formation. In this review, we analyze the molecular mechanisms, involved in tumor-induced bone disease and discuss the current therapeutic approaches and the most recent clinical developments of emerging targeted therapies.

Place, publisher, year, edition, pages
2011. Vol. 18, no 11, 1584-1598 p.
Keyword [en]
Bone disease, cancer, multiple myeloma, molecular targeting, osteoblasts, osteoclasts
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-153643ISI: 000289975200003PubMedID: 21428887OAI: oai:DiVA.org:uu-153643DiVA: diva2:417408
Available from: 2011-05-17 Created: 2011-05-17 Last updated: 2011-05-17Bibliographically approved

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