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Clinical trial: colectomy after resue therapy in ulcerative colitis-3-year follow-up of the Swedish-Danish controlled infliximab study
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2010 (English)In: Alimentary Pharmacology and Therapeutics, ISSN 0269-2813, E-ISSN 1365-2036, Vol. 32, no 8, 984-989 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND:

The long-term efficacy of infliximab as rescue therapy in steroid-refractory ulcerative colitis is not well described.

AIM:

To examine the long-term efficacy of infliximab as a rescue therapy through a 3-year follow-up of a previous placebo-controlled trial of infliximab in acute steroid-refractory ulcerative colitis.

METHOD:

In the original study, 45 patients were randomized to a single infusion of infliximab 5 mg/kg or placebo, and at 3 months, 7/24 patients given infliximab were operated vs. 14/21 patients given placebo. Three years or later, patients were asked to participate in a clinical follow-up.

RESULTS:

Another seven patients underwent colectomy during follow-up: five in the infliximab group and two in the placebo group. After 3 years, a total of 12/24 (50%) patients given infliximab and 16/21 (76%) given placebo (P = 0.012) had a colectomy. None of eight patients in endoscopic remission at 3 months later had a colectomy compared with 7/14 (50%) patients who were not in remission (P=0.02). There was no mortality.

CONCLUSION:

The benefit of rescue therapy with infliximab in steroid-refractory acute ulcerative colitis remained after 3 years. The main advantage of infliximab treatment occurred during the first 3 months, whereas subsequent colectomy rates were similar in the two groups. Mucosal healing at 3 months influenced later risk of colectomy.

Place, publisher, year, edition, pages
2010. Vol. 32, no 8, 984-989 p.
National Category
Gastroenterology and Hepatology
Research subject
Medical Science
Identifiers
URN: urn:nbn:se:uu:diva-153899DOI: 10.1111/j.1365-2036.2010.04435.xPubMedID: 20937043OAI: oai:DiVA.org:uu-153899DiVA: diva2:418251
Available from: 2011-05-20 Created: 2011-05-20 Last updated: 2017-12-11Bibliographically approved

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Hellström, Per M.

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