uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Influence of Physical Exercise on Neuroimmunological Functioning and Health: Aging and Stress
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Psychiatry, Ulleråker, University Hospital.
2011 (English)In: Neurotoxicity research, ISSN 1029-8428, Vol. 20, no 1, 69-83 p.Article in journal (Refereed) Published
Abstract [en]

Chronic and acute stress, with associated pathophysiology, are implicated in a variety of disease states, with neuroimmunological dysregulation and inflammation as major hazards to health and functional sufficiency. Psychosocial stress and negative affect are linked to elevations in several inflammatory biomarkers. Immunosenescence, the deterioration of immune competence observed in the aged aspect of the life span, linked to a dramatic rise in morbidity and susceptibility to diseases with fatal outcomes, alters neuroimmunological function and is particularly marked in the neurodegenerative disorders, e.g., Parkinson's disease and diabetes. Physical exercise diminishes inflammation and elevates agents and factors involved in immunomodulatory function. Both the alleviatory effects of life-long physical activity upon multiple cancer forms and the palliative effects of physical activity for individuals afflicted by cancer offer advantages in health intervention. Chronic conditions of stress and affective dysregulation are associated with neuroimmunological insufficiency and inflammation, contributing to health risk and mortality. Physical exercise regimes have induced manifest anti-inflammatory benefits, mediated possibly by brain-derived neurotrophic factor. The epidemic proportions of metabolic disorders, obesity, and diabetes demand attention; several variants of exercise regimes have been found repeatedly to induce both prevention and improvement under both laboratory and clinical conditions. Physical exercise offers a unique non-pharmacologic intervention incorporating multiple activity regimes, e.g., endurance versus resistance exercise that may be adapted to conform to the particular demands of diagnosis, intervention and prognosis inherent to the staging of autoimmune disorders and related conditions.

Place, publisher, year, edition, pages
2011. Vol. 20, no 1, 69-83 p.
Keyword [en]
Exercise, Inflammation, Cancer, Diabetes, Stress, Markers, Immunosenescence, Neuroimmune function
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-153947DOI: 10.1007/s12640-010-9224-9ISI: 000290318700008PubMedID: 20953749OAI: oai:DiVA.org:uu-153947DiVA: diva2:419198
Available from: 2011-05-26 Created: 2011-05-23 Last updated: 2011-05-26Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
By organisation
Psychiatry, Ulleråker, University Hospital
In the same journal
Neurotoxicity research
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 236 hits
ReferencesLink to record
Permanent link

Direct link