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Mesoporous silica particles induce size dependent effects on human dendritic cells
Karolinska Institutet.
Karolinska Institutet.
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Nanotechnology and Functional Materials.
Karolinska Institutet.
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2007 (English)In: Nano letters (Print), ISSN 1530-6984, E-ISSN 1530-6992, Vol. 7, no 12, 3576-3582 p.Article in journal (Other academic) Published
Abstract [en]

The effects of mesoporous silica nano- (270 nm) and microparticles (2.5 μm) with surface areas above 500 m2/g were evaluated on human monocyte-derived dendritic cells (MDDC). Size- and concentration-dependent effects were seen where the smaller particles and lower concentrations affected MDDC to a minor degree compared to the larger particles and higher concentrations, both in terms of viability, uptake, and immune regulatory markers. Our findings support the further development of mesoporous silica particles in drug and vaccine delivery systems.

Place, publisher, year, edition, pages
2007. Vol. 7, no 12, 3576-3582 p.
National Category
Natural Sciences Engineering and Technology
URN: urn:nbn:se:uu:diva-14171DOI: 10.1021/nl0714785ISI: 000251581600005PubMedID: 17975942OAI: oai:DiVA.org:uu-14171DiVA: diva2:41941
Available from: 2008-01-29 Created: 2008-01-29 Last updated: 2016-04-07Bibliographically approved

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Strömme, MariaGarcia Bennett, Alfonso E
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