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A Novel Poly(L-Lactide-co-e-Caprolactone)-Collagen Hybrid Construct for Application in Tissue Engineering
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Materials Chemistry, Polymer Chemistry. (polymerkemi)
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2007 (English)In: Termis-EU Meeting Abstracts, London, UK September 4-7 2007: [Published in Tissue Engineering, vol. 13, nr. 7], Mary Ann Liebert Inc. , 2007, 1637-1637 p.Conference paper (Other academic)
Abstract [en]

A biodegradable hybrid construct consisting of a slow degrading poly(L-lactide-co-e-caprolactone) (PLA-e-CL) knitted mesh, plastically compressed (1) between two collagen gels was fabricated and tested in vitro for tissue engineering applications. The polymer mesh was incorporated to give greater mechanical stability to the compressed collagen scaffolds.

The hybrid construct was characterized for fluid (weight) loss and cell viability during compression and mechanical properties.

Hybrid constructs embedded and surface layered with human dermal

fibroblasts (2, Eþ5 per 5 ml) were cultured for up to one week

in static culture. Quantitative and qualitative data on cell viability

and proliferation were obtained.

It was found that the fluid (weight) loss in plastic compression

of the hybrid construct was time dependent and not weight dependent

at an applied load of 240 grams. No significant cell death

was observed during the plastic compression process and a homogenous

cell distribution was achieved. One week of static culture

showed that the cultivated hybrid construct retained its

mechanical properties with no evidence of degradation, and cells

inside the constructs as well as layered on top of the constructs


We found the PLA-e-CL-Collagen hybrid construct a useful

three-dimensional scaffold for tissue engineering of stratified tissues

and potential applications in bladder wall, blood vessels and

skin are currently being explored.

Place, publisher, year, edition, pages
Mary Ann Liebert Inc. , 2007. 1637-1637 p.
National Category
Inorganic Chemistry
URN: urn:nbn:se:uu:diva-14186DOI: 10.1089/ten.2007.1501OAI: oai:DiVA.org:uu-14186DiVA: diva2:41956
Available from: 2008-01-29 Created: 2008-01-29 Last updated: 2011-03-17Bibliographically approved

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Publisher's full texthttp://www.liebertonline.com/doi/pdfplus/10.1089/ten.2007.1501

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