uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Abnormal function of C-fibers in patients with diabetic neuropathy
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
Show others and affiliations
2006 (English)In: Journal of Neuroscience, ISSN 0270-6474, E-ISSN 1529-2401, Vol. 26, no 44, 11287-11294 p.Article in journal (Refereed) Published
Abstract [en]

The mechanisms underlying the development of painful and nonpainful neuropathy associated with diabetes mellitus are unclear. We have obtained microneurographic recordings from unmyelinated fibers in eight patients with diabetes mellitus, five with painful neuropathy, and three with neuropathy without pain. All eight patients had large-fiber neuropathy, and seven patients had pathological thermal thresholds in their feet, indicating the involvement of small-caliber nerve fibers. A total of 163 C-fibers were recorded at knee level from the common peroneal nerve in the patients (36-67 years old), and these were compared with 77 C-fibers from healthy controls (41-64 years old). The ratio of mechano-responsive to mechano-insensitive nociceptors was similar to 2:1 in the healthy controls, whereas in the patients, it was 1:2. In patients, a fairly large percentage of characterized fibers (12.5% in nonpainful and 18.9% in painful neuropathy) resembled mechano-responsive nociceptors that had lost their mechanical and heat responsiveness. Such fibers were rarely encountered in age-matched controls (3.2%). Afferent fibers with spontaneous activity or mechanical sensitization were found in both patient groups. We conclude that small-fiber neuropathy in diabetes affects receptive properties of nociceptors that leads to an impairment of mechano-responsive nociceptors.

Place, publisher, year, edition, pages
2006. Vol. 26, no 44, 11287-11294 p.
Keyword [en]
neuropathy, diabetes, pain, C-fibers, microneurography, degeneration
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-14199DOI: 10.1523/JNEUROSCI.2659-06.2006ISI: 000241727500007PubMedID: 17079656OAI: oai:DiVA.org:uu-14199DiVA: diva2:41969
Available from: 2008-01-29 Created: 2008-01-29 Last updated: 2011-05-13Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Schmidt, RolandHandwerker, H.Torebjörk, Erik
By organisation
Department of Neuroscience
In the same journal
Journal of Neuroscience
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 141 hits
ReferencesLink to record
Permanent link

Direct link