uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
First-Ever Atrial Fibrillation Documented After Hemorrhagic or Ischemic Stroke: The Role of the CHADS(2) Score at the Time of Stroke
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Show others and affiliations
2011 (English)In: Clinical Cardiology, ISSN 0160-9289, E-ISSN 1932-8737, Vol. 34, no 5, 309-316 p.Article in journal (Refereed) Published
Abstract [en]

Background: The CHADS(2) score (C, congestive heart failure [CHF]; H, hypertension [HT]; A, age >= 75 y; D, diabetes mellitus; S-2, prior stroke or transient ischemic attack) is used to assess the risk of ischemic stroke in patients with atrial fibrillation (AF). However, its role in patients without documented AF is not well explored. Hypothesis: The goal of the current study was to explore if the incidence of hospitalization with first-ever AF after stroke increased with increasing CHADS(2) score. Methods: We identified 57 636 patients with nonfatal stroke and no documented AF in the Swedish Stroke Register (Riks-Stroke) during 2001-2004 and followed them for a mean of 2.2 years through record linkage to the Inpatient and Cause of Death registers. Cox regression hazard models were used to estimate the relative risk (RR) of new AF following stroke and its association with different CHADS(2) scores. Results: Overall, 2769 patients were hospitalized with new AF (4.8%, 21.7 per 1000 person-years). The incidence increased from 9.6 per 1000 person-years in CHADS(2) score 0 to 42.7 in CHADS(2) score 6, conferring a RR of 4.2 (95% confidence interval [CI]: 2.5-6.8). For CHADS(2) scores 3-5, the RRs were approximately 3 (vs CHADS(2) score 0). Adjusted RRs were 1.9 (95% CI: 1.7-2.1) for CHF, 1.4 (95% CI: 1.3-1.5) for HT, 2.1 (95% CI: 2.0-2.3) for age >= 75 years, 0.9 (95% CI: 0.8-1.0) for diabetes, and 1.0 (95% CI: 0.91-1.07) for previous stroke. The risk of AF was higher in ischemic than in hemorrhagic stroke. Conclusions: In this retrospective register study, the incidence of AF following stroke was strongly influenced by higher CHADS(2) scores where age >= 75 years, CHF, and HT were the contributing CHADS(2) components.

Place, publisher, year, edition, pages
2011. Vol. 34, no 5, 309-316 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-154302DOI: 10.1002/clc.20869ISI: 000290522700006PubMedID: 21400547OAI: oai:DiVA.org:uu-154302DiVA: diva2:419868
Available from: 2011-05-30 Created: 2011-05-30 Last updated: 2011-05-30Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
By organisation
Department of Medical Sciences
In the same journal
Clinical Cardiology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 135 hits
ReferencesLink to record
Permanent link

Direct link