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TAR-DNA binding protein-43 and alterations in the hippocampus
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2011 (English)In: Journal of neural transmission, ISSN 0300-9564, E-ISSN 1435-1463, Vol. 118, no 5, 683-689 p.Article in journal (Refereed) Published
Abstract [en]

Immunocytochemistry for transactive response binding protein-43 (TDP43) was assessed in the granular cell layer of the dentate gyrus in 250 cases displaying hippocampal pathology identified by haematoxylin-eosin staining. 18%, nearly one in five displayed TDP43 immunoreactive pathology in the granular cell layer of hippocampus. This percentage increased to 43% when only subjects with hippocampal pathology other than vascular in origin were included. When only subjects with severe Alzheimer's disease-related pathology were included, 42% displayed TDP43-immunoreactive pathology, increasing to 60% when concomitant Alzheimer's disease and alpha-synuclein pathology were present. Within this setting, TDP43-immunoreactive pathology was observed to be present in 6% of subjects with hippocampal pathology but without any cognitive impairment. Our findings justify assessment of TDP43 pathology in every case where a pathological alteration is observed in the hippocampus using a routine stain.

Place, publisher, year, edition, pages
2011. Vol. 118, no 5, 683-689 p.
Keyword [en]
TAR-DNA binding protein-43, Hyperphosphorylated-tau, p62, Immunohistochemistry, Post-mortem, Hippocampal alterations
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-154292DOI: 10.1007/s00702-010-0574-5ISI: 000290542500005PubMedID: 21210283OAI: oai:DiVA.org:uu-154292DiVA: diva2:419922
Available from: 2011-05-30 Created: 2011-05-30 Last updated: 2011-05-30Bibliographically approved

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