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NMR Studies on the interaction between (−)-epigallocatechin gallate and cyclodextrins, free and bonded to silica gels
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Physical and Analytical Chemistry, Surface Biotechnology.
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2007 (English)In: Carbohydrate Research, ISSN 0008-6215, E-ISSN 1873-426X, Vol. 342, no 6, 843-850 p.Article in journal (Refereed) Published
Abstract [en]

The interaction between (−)-epigallocatechin-3-gallate (EGCG) and β- or γ-cyclodextrin (CD), in free solution and bonded to silica beads, has been studied by 1H HR-MAS NMR spectroscopy. The chromatographic retardation of EGCG on columns packed with CD-silica beads was shown to be due to the interaction of EGCG with the CD ligands because no nonspecific interaction with the silica gel could be observed. EGCG forms a tighter complex with β-CD than with γ-CD and NMR data obtained from hydroxy protons together with mm2 calculations suggest that for β-CD intermolecular hydrogen bonding, in addition to hydrophobic interaction, stabilizes the complex.

Place, publisher, year, edition, pages
2007. Vol. 342, no 6, 843-850 p.
Keyword [en]
Cyclodextrins, Epigallocatechin gallate, HR-MAS NMR, Silica beads
National Category
Chemical Sciences
URN: urn:nbn:se:uu:diva-14223DOI: 10.1016/j.carres.2007.01.007ISI: 000245396700008PubMedID: 17270160OAI: oai:DiVA.org:uu-14223DiVA: diva2:41993
Available from: 2008-01-29 Created: 2008-01-29 Last updated: 2011-04-07Bibliographically approved

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