uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Inflammatory S100A9 and S100A12 proteins in Alzheimer's disease
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology, Integrativ Fysiologi.
Show others and affiliations
2006 (English)In: Neurobiology of Aging, ISSN 0197-4580, E-ISSN 1558-1497, Vol. 27, no 11, 1554-1563 p.Article in journal (Refereed) Published
Abstract [en]

Inflammation, insoluble protein deposition and neuronal cell loss are important features of the Alzheimer's disease (AD) brain. S100B is associated with the neuropathological hallmarks of AD where it is thought to play a role in neuritic pathology. S100A8, S100A9 and S100A12 comprise anew group of inflammation-associated proteins that are constitutively expressed by neutrophils and inducible in numerous inflammatory cells. We investigated expression of S100B, S100A8, S100A9 and S100A12 in brain samples from sporadic and familial (PS-1) AD cases and controls using immunohistochemistry and Western blot analysis. S100B, S100A9 and S100A12, but not S100A8, were consistently associated with the neuropathological hallmarks of AD. Western blot analysis confirmed significant increases in soluble S100A9 in PS-1 AD compared to controls. S100A9 complexes that were resistant to reduction were also evident in brain extracts. A reactive component of a size consistent with hexameric S100A12 was seen in all cases. This study indicates a potential role for pro-inflammatory S100A9 and S100A12 in pathogenesis caused by inflammation and protein complex formation in AD.

Place, publisher, year, edition, pages
2006. Vol. 27, no 11, 1554-1563 p.
Keyword [en]
Alzheimer's disease, S100 proteins, inflammation, presenilin 1
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-154427DOI: 10.1016/j.neurobiolaging.2005.09.033ISI: 000240969500002PubMedID: 16253391OAI: oai:DiVA.org:uu-154427DiVA: diva2:420352
Available from: 2011-06-01 Created: 2011-06-01 Last updated: 2011-06-01Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
By organisation
Integrativ Fysiologi
In the same journal
Neurobiology of Aging
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 139 hits
ReferencesLink to record
Permanent link

Direct link