PROX1 is a predictor of survival for gliomas WHO grade II
2011 (English)In: British Journal of Cancer, ISSN 0007-0920, E-ISSN 1532-1827, Vol. 104, no 11, 1747-1754 p.Article in journal (Refereed) Published
Background:The clinical course of World Health Organisation grade II gliomas remains variable and their time point of transformation into a more malignant phenotype is unpredictable. Identification of biological markers that can predict prognosis in individual patients is of great clinical value. PROX1 is a transcription factor that has a critical role in the development of various organs. PROX1 has been ascribed both oncogenic and tumour suppressive functions in human cancers. We have recently shown that PROX1 may act as a diagnostic marker for high-grade gliomas. The aim of this study was to address the prognostic value of PROX1 in grade II gliomas.Methods:A total of 116 samples were evaluated for the presence of PROX1 protein. The number of immunopositive cells was used as a variable in survival analysis, together with established prognostic factors for this patient group.Results:Higher PROX1 protein was associated with poor outcome. In the multivariate analysis, PROX1 was identified as an independent factor for survival (P=0.024), together with the presence of mutated isocitrate dehydrogenase 1 R132H protein, and with combined losses of chromosomal arms 1p/19q in oligodendrocytic tumours.Conclusion:PROX1 is a novel predictor of survival for grade II gliomas.
Place, publisher, year, edition, pages
2011. Vol. 104, no 11, 1747-1754 p.
low-grade glioma, astrocytoma, oligodendroglioma, PROX1, prognosis, survival
Research subject Neurology
IdentifiersURN: urn:nbn:se:uu:diva-154452DOI: 10.1038/bjc.2011.162ISI: 000290953200014PubMedID: 21559010OAI: oai:DiVA.org:uu-154452DiVA: diva2:420505