uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Dynamics of the immune response against extracellular products of group A streptococci during infection
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Infectious Diseases.
Show others and affiliations
2007 (English)In: Clinical and Vaccine Immunology, ISSN 1556-6811, Vol. 14, no 1, 44-51 p.Article in journal (Refereed) Published
Abstract [en]

The immune response against the infecting group A streptococcus (GAS) extracellular products (EP) was determined in acute- and convalescent-phase sera from 75 patients with different clinical manifestations of GAS infection. All EP elicited a high proliferative response in human peripheral blood mononuclear cells. In patients with bacteremia, low neutralization in acute-phase sera was associated with development of streptococcal toxic shock syndrome. Lack of neutralization in acute-phase sera was more common in patients infected with the T1emm1 serotype. The majority of patients did not develop the ability to neutralize the mitogenic activity of their infecting isolate despite a significant increase in enzyme-linked immunosorbent assay titer in early convalescent-phase sera. In patients with the ability to neutralize GAS EP, the immune response remained high over at least 3 years. In contrast, the neutralization capacity conferred by intravenous immunoglobulin and/or plasma treatment disappeared within 3 months.

Place, publisher, year, edition, pages
2007. Vol. 14, no 1, 44-51 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-14283DOI: 10.1128/CVI.00271-06ISI: 000243546100004PubMedID: 17093101OAI: oai:DiVA.org:uu-14283DiVA: diva2:42053
Available from: 2008-01-29 Created: 2008-01-29 Last updated: 2011-04-07Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Pauksens, Karlis
By organisation
Infectious Diseases
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 165 hits
ReferencesLink to record
Permanent link

Direct link