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TGF-beta Signaling in Breast Cancer Cell Invasion and Bone Metastasis
Department of Molecular Cell Biology and Centre for Biomedical Genetics, Leiden University Medical Center, Postbus 9600, 2300 RC Leiden, The Netherlands.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
2011 (English)In: Journal of mammary gland biology and neoplasia, ISSN 1083-3021, E-ISSN 1573-7039, Vol. 16, no 2, 97-108 p.Article in journal (Refereed) Published
Abstract [en]

The contribution of transforming growth factor beta (TGF-beta) signaling to breast cancer has been studied for more than two decades. In an early phase TGF-beta may act as a tumour suppressor, while later, when cells have become resistant to its anti-mitogenic effects, the role of TGF-beta switches towards malignant conversion and progression. TGF-beta stimulates cell invasion and modifies the microenvironment to the advantage of cancer cells. Studies have shown that TGF-beta promotes bone and lung metastasis via different mechanisms. The therapeutic strategies to target the TGF-beta pathway in breast cancer are becoming increasingly clear. This review will focus on the role TGF-beta in breast cancer invasion and metastasis.

Place, publisher, year, edition, pages
Springer , 2011. Vol. 16, no 2, 97-108 p.
Keyword [en]
EMT, Invasion, Metastasis, Microenvironment, Stroma, TGF-beta
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-154543DOI: 10.1007/s10911-011-9217-1ISI: 000290683500005PubMedID: 21494783OAI: oai:DiVA.org:uu-154543DiVA: diva2:420986
Available from: 2011-06-07 Created: 2011-06-07 Last updated: 2012-02-15Bibliographically approved

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