TGF-beta Signaling in Breast Cancer Cell Invasion and Bone Metastasis
2011 (English)In: Journal of mammary gland biology and neoplasia, ISSN 1083-3021, E-ISSN 1573-7039, Vol. 16, no 2, 97-108 p.Article in journal (Refereed) Published
The contribution of transforming growth factor beta (TGF-beta) signaling to breast cancer has been studied for more than two decades. In an early phase TGF-beta may act as a tumour suppressor, while later, when cells have become resistant to its anti-mitogenic effects, the role of TGF-beta switches towards malignant conversion and progression. TGF-beta stimulates cell invasion and modifies the microenvironment to the advantage of cancer cells. Studies have shown that TGF-beta promotes bone and lung metastasis via different mechanisms. The therapeutic strategies to target the TGF-beta pathway in breast cancer are becoming increasingly clear. This review will focus on the role TGF-beta in breast cancer invasion and metastasis.
Place, publisher, year, edition, pages
Springer , 2011. Vol. 16, no 2, 97-108 p.
EMT, Invasion, Metastasis, Microenvironment, Stroma, TGF-beta
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-154543DOI: 10.1007/s10911-011-9217-1ISI: 000290683500005PubMedID: 21494783OAI: oai:DiVA.org:uu-154543DiVA: diva2:420986