uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Acute sleep deprivation reduces energy expenditure in healthy men
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Functional Pharmacology.ORCID iD: 000-0002-8911-4068
Show others and affiliations
2011 (English)In: American Journal of Clinical Nutrition, ISSN 0002-9165, E-ISSN 1938-3207, Vol. 93, no 6, 1229-1236 p.Article in journal (Refereed) Published
Abstract [en]


Epidemiologic evidence indicates that chronic sleep curtailment increases risk of developing obesity, but the mechanisms behind this relation are largely unknown.


We examined the influence of a single night of total sleep deprivation on morning energy expenditures and food intakes in healthy humans.


According to a balanced crossover design, we examined 14 normal-weight male subjects on 2 occasions during a regular 24-h sleep-wake cycle (including 8 h of nocturnal sleep) and a 24-h period of continuous wakefulness. On the morning after regular sleep and total sleep deprivation, resting and postprandial energy expenditures were assessed by indirect calorimetry, and the free-choice food intake from an opulent buffet was tested in the late afternoon at the end of the experiment. Circulating concentrations of ghrelin, leptin, norepinephrine, cortisol, thyreotropin, glucose, and insulin were repeatedly measured over the entire 24-h session.


In comparison with normal sleep, resting and postprandial energy expenditures assessed on the subsequent morning were significantly reduced after sleep deprivation by approximate to 5% and 20%, respectively (P < 0.05 and P < 0.0001). Nocturnal wakefulness increased morning plasma ghrelin concentrations (P < 0.02) and nocturnal and daytime circulating concentrations of thyreotropin, cortisol, and norepinephrine (P < 0.05) as well as morning postprandial plasma glucose concentrations (P < 0.05). Changes in food intakes were variable, and no differences between wake and sleep conditions were detected.


Our findings show that one night of sleep deprivation acutely reduces energy expenditure in healthy men, which suggests that sleep contributes to the acute regulation of daytime energy expenditure in humans.

Place, publisher, year, edition, pages
2011. Vol. 93, no 6, 1229-1236 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-154681DOI: 10.3945/ajcn.110.006460ISI: 000290796700009PubMedID: 21471283OAI: oai:DiVA.org:uu-154681DiVA: diva2:421712
Available from: 2011-06-09 Created: 2011-06-09 Last updated: 2015-02-23Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Benedict, ChristianSchiöth, Helgi Birgir
By organisation
Functional Pharmacology
In the same journal
American Journal of Clinical Nutrition
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 300 hits
ReferencesLink to record
Permanent link

Direct link