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TNM staging of foregut (neuro)endocrine tumors: a consensus proposal including a grading system
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2006 (English)In: Virchows Archiv, ISSN 0945-6317, E-ISSN 1432-2307, Vol. 449, no 4, 395-401 p.Article in journal (Refereed) Published
Abstract [en]

The need for standards in the management of patients with endocrine tumors of the digestive system prompted the European Neuroendocrine Tumor Society (ENETS) to organize a first Consensus Conference, which was held in Frascati (Rome) and was based on the recently published ENETS guidelines on the diagnosis and treatment of digestive neuroendocrine tumors (NET). Here, we report the tumor-node-metastasis proposal for foregut NETs of the stomach, duodenum, and pancreas that was designed, discussed, and consensually approved at this conference. In addition, we report the proposal for a working formulation for the grading of digestive NETs based on mitotic count and Ki-67 index. This proposal, which needs to be validated, is meant to help clinicians in the stratification, treatment, and follow-up of patients.

Place, publisher, year, edition, pages
2006. Vol. 449, no 4, 395-401 p.
Keyword [en]
neuroendocrine tumors, gut, pancreas, staging, TNM, grading, mitotic index, Ki-67 index
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-154750DOI: 10.1007/s00428-006-0250-1ISI: 000240723800001PubMedID: 16967267OAI: oai:DiVA.org:uu-154750DiVA: diva2:422392
Available from: 2011-06-13 Created: 2011-06-10 Last updated: 2011-06-13Bibliographically approved

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