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Immunoglobulin sequence analysis and prognostication in CLL: guidelines from the ERIC review board for reliable interpretation of problematic cases
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2011 (English)In: Leukemia, ISSN 0887-6924, E-ISSN 1476-5551, Vol. 25, no 6, 979-984 p.Article in journal (Refereed) Published
Abstract [en]

prognostication in chronic lymphocytic leukemia (CLL) and the definition of standardized procedures has allowed reliable and reproducible results. Occasionally, a straightforward interpretation of the sequences is not possible because of the so-called 'problematic sequences' that do not fit the 'classic' interpretation and pose scientific questions at the cross-road between hematology and immunology. Thanks to a dedicated effort within the European Research Initiative on CLL (ERIC), we have now the possibility to present such cases, offer a scientific explanation and propose recommendations in terms of prognostication.

Place, publisher, year, edition, pages
2011. Vol. 25, no 6, 979-984 p.
Keyword [en]
CLL, immunoglobulin, prognosis, IGHV, somatic mutation analysis
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-155231DOI: 10.1038/leu.2011.49ISI: 000291386900011OAI: oai:DiVA.org:uu-155231DiVA: diva2:425472
Available from: 2011-06-21 Created: 2011-06-20 Last updated: 2011-06-21Bibliographically approved

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Murray, FionaRosenquist, Richard
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Department of Immunology, Genetics and Pathology
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