uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Collaborative meta-analysis of individual participant data from observational studies of Lp-PLA2 and cardiovascular diseases
Show others and affiliations
2007 (English)In: European Journal of Cardiovascular Prevention & Rehabilitation, ISSN 1741-8267, E-ISSN 1741-8275, Vol. 14, no 1, 3-11 p.Article, review/survey (Refereed) Published
Abstract [en]

BACKGROUND: A large number of observational epidemiological studies have reported generally positive associations between circulating mass and activity levels of lipoprotein-associated phospholipase A2 (Lp-PLA2) and the risk of cardiovascular diseases. Few studies have been large enough to provide reliable estimates in different circumstances, such as in different subgroups (e.g., by age group, sex, or smoking status) or at different Lp-PLA2 levels. Moreover, most published studies have related disease risk only to baseline values of Lp-PLA2 markers (which can lead to substantial underestimation of any risk relationships because of within-person variability over time) and have used different approaches to adjustment for possible confounding factors. OBJECTIVES: By combination of data from individual participants from all relevant observational studies in a systematic 'meta-analysis', with correction for regression dilution (using available data on serial measurements of Lp-PLA2), the Lp-PLA2 Studies Collaboration will aim to characterize more precisely than has previously been possible the strength and shape of the age and sex-specific associations of plasma Lp-PLA2 with coronary heart disease (and, where data are sufficient, with other vascular diseases, such as ischaemic stroke). It will also help to determine to what extent such associations are independent of possible confounding factors and to explore potential sources of heterogeneity among studies, such as those related to assay methods and study design. It is anticipated that the present collaboration will serve as a framework to investigate related questions on Lp-PLA2 and cardiovascular outcomes. METHODS: A central database is being established containing data on circulating Lp-PLA2 values, sex and other potential confounding factors, age at baseline Lp-PLA2 measurement, age at event or at last follow-up, major vascular morbidity and cause-specific mortality. Information about any repeat measurements of Lp-PLA2 and potential confounding factors has been sought to allow adjustment for possible confounding and correction for regression dilution. The analyses will involve age-specific regression models. Synthesis of the available observational studies of Lp-PLA2 will yield information on a total of about 15 000 cardiovascular disease endpoints.

Place, publisher, year, edition, pages
2007. Vol. 14, no 1, 3-11 p.
Keyword [en]
1-Alkyl-2-acetylglycerophosphocholine Esterase/*metabolism, Cardiovascular Diseases/*epidemiology/*metabolism, Humans, Phospholipases A2
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-14801DOI: 10.1097/01.hjr.0000239464.18509.f1ISI: 000244796200002PubMedID: 17301621OAI: oai:DiVA.org:uu-14801DiVA: diva2:42572
Available from: 2008-01-31 Created: 2008-01-31 Last updated: 2011-03-29Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=17301621&dopt=Citation

Search in DiVA

By author/editor
Oldgren, J.James, Stefan
By organisation
UCR-Uppsala Clinical Research CenterDepartment of Surgical Sciences
In the same journal
European Journal of Cardiovascular Prevention & Rehabilitation
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 207 hits
ReferencesLink to record
Permanent link

Direct link