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Appendiceal Adenocarcinoids with Peritoneal Carcinomatosis Treated with Cytoreductive Surgery and Intraperitoneal Chemotherapy: a retrospective study of in vitro drug sensitivity and survival
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Colorectal Surgery.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Oncology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Endocrine Surgery.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Onkologisk endokrinologi)
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2011 (English)In: Clinical Colorectal Cancer, ISSN 1533-0028, Vol. 10, no 2, 108-112 p.Article in journal (Refereed) Published
Abstract [en]

Purpose: The purpose of this study was to present results on cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) of appendiceal adenocarcinoid (MC) with peritoneal carcinomatosis (PC), to assess drug sensitivity of AAC, as compared with colorectal cancer (CRC), and to report any discordant histopathology.

Methods: Ten patients were treated with CRS and HIPEC. Treatment, drug sensitivity profiles, histopathology, and survival data were recorded and matched with potential prognostic indicators. Drug sensitivity was assessed with short-term fluorometric microculture cytotoxicity assay and compared with peritoneal metastases from CRC.

Results: Patients with completeness of cytoreduction score (CC) 1 (16.4 months). In the CC 1 group. For standard drugs, tumor cells from MC and CRC were equally sensitive; except for docetaxel, to which MC was more sensitive than CRC.

Conclusion: The CC-score correlated with overall survival. Candidates for this type of treatment should be referred early for evaluation in order to reach a better CC score. Drugs used for CRC also seem adequate for treatment of MC, although other drugs, eg, docetaxel, might be more active.

Place, publisher, year, edition, pages
2011. Vol. 10, no 2, 108-112 p.
Keyword [en]
Adenocarcinoid, Cytoreductive surgery, Drug sensitivity, FMCA, HIPEC, Peritoneal carcinomatosis
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-155390DOI: 10.1016/j.clcc.2011.03.006ISI: 000291297000006OAI: oai:DiVA.org:uu-155390DiVA: diva2:426053
Available from: 2011-06-22 Created: 2011-06-22 Last updated: 2012-04-25Bibliographically approved

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Cashin, PeterNygren, PeterHellman, PerGranberg, DanAndréasson, HåkanMahteme, Haile

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