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Mast cell progenitor trafficking and maturation
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
2011 (English)In: Advances in Experimental Medicine and Biology, ISSN 0065-2598, Vol. 716, no Section II, 14-28 p.Article in journal (Other academic) Published
Abstract [en]

Mast cells are derived from the hematopoietic progenitors found in bone marrow and spleen. Committed mast cell progenitors are rare in bone marrow suggesting they are rapidly released into the blood where they circulate and move out into the peripheral tissues. This migration is controlled in a tissue specific manner. Basal trafficking to the intestine requires expression of alpha 4 beta 7 integrin and the chemokine receptor CXCR2 by the mast cell progenitors and expression of MAdCAM-1 and VCAM-1 in the intestinal endothelium; and is also controlled by dendritic cells expressing the transcriptional regulatory protein T-bet. None of these play a role in basal trafficking to the lung. With the induction of allergic inflammation in the lung, there is marked recruitment of committed mast cell progenitors to lung and these cells must express alpha 4 beta 7 and alpha 4 beta 1 integrins. Within the lung there is a requirement for expression of VCAM-1 on the endothelium that is regulated by CXCR2, also expressed on the endothelium. There is a further requirement for expression of the CCR2/CCL2 pathways for full recruitment of the mast cell progenitors to the antigen-inflamed lung.

Place, publisher, year, edition, pages
2011. Vol. 716, no Section II, 14-28 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-155230DOI: 10.1007/978-1-4419-9533-9_2ISI: 000290066600002OAI: oai:DiVA.org:uu-155230DiVA: diva2:426298
Available from: 2011-06-23 Created: 2011-06-20 Last updated: 2012-02-28Bibliographically approved

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Hallgren, Jenny
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