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Antihyperglycaemic treatment of type 2 diabetes: results from a national diabetes register
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Clinical Epidemiology.
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2007 (English)In: Diabetes & Metabolism, ISSN 1262-3636, Vol. 33, no 4, 269-276 p.Article in journal (Refereed) Published
Abstract [en]


To describe clinical characteristics and antihyperglycaemic treatment patterns in patients with varying duration of diabetes.


We performed a cross-sectional survey of 61 890 type 2 diabetic (DM2) patients from the Swedish National Diabetes Register (NDR) in 2004. We also analysed the effect of types of treatment and risk factors on glycaemic control in a longitudinal cohort study from 1996 to 2004. HbA1c, risk factors and treatments were determined locally in primary care as well as hospital outpatient clinics.


Insulin was frequently used in DM2 patients with long duration of diabetes, although the mean HbA1c increased and only a few in this group reached HbA1c < 7.0%. Patients showing long-term improvement in HbA1c (> 1%) from 1996 to 2004 were more often treated with insulin than with oral hypoglycaemic agents (OHA). During this period, the HbA1c levels leading to additional treatment decreased. A low BMI, decreasing BMI and not smoking were predictors of good long-term metabolic control. Hypertension and hyperlipidaemia were frequent in both newly diagnosed DM2 patients and in patients with a long duration of diabetes.


Insulin treatment was frequently used, particularly in patients with a long duration of DM2. The glycaemic control, which usually deteriorates over time, did not reach the recommended goal, despite the fact that complementary treatment was added at lower HbA1c levels in 2003 than in 1996. High frequencies of hypertension, hyperlipidaemia and high 10-year risks of coronary heart disease necessitate intensified risk factor control in the future.

Place, publisher, year, edition, pages
2007. Vol. 33, no 4, 269-276 p.
Keyword [en]
Diabetes mellitus, Epidemiology, Insulin, Hypoglycaemic agents, Hypertension, National register
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-14871DOI: 10.1016/j.diabet.2007.02.003ISI: 000250111600005PubMedID: 17499541OAI: oai:DiVA.org:uu-14871DiVA: diva2:42642
Available from: 2008-01-31 Created: 2008-01-31 Last updated: 2011-01-27Bibliographically approved

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Publisher's full textPubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=17499541&dopt=Citation

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