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Tumour incidence in Swedish women who gave birth following IVF treatment
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Clinical Epidemiology.
2007 (English)In: Human Reproduction, ISSN 0268-1161, E-ISSN 1460-2350, Vol. 22, no 2, 421-426 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Possible effects on maternal tumour incidence of a full-term pregnancy following IVF treatment with indicated supraphysiologic steroid and peptide hormonal levels in pregnancy remain uncertain. METHODS: National registries were used to compare incidence of non-invasive and invasive tumour disease in Swedish women with live birth following IVF treatment with women with live birth without IVF. RESULTS: The study had a mean follow-up period of 6.2 years in the IVF group and 7.8 years in the non-IVF group, and the mean gestation period (s.d.) for IVF and non-IVF group was 271.0 (21.1) days and 278.5 (14.1) days, respectively. In a multivariate Poisson regression analysis, adjusted rate ratios of 0.70 (0.52-0.92) and 0.93 (0.58-1.43) among IVF women were found for the risk of carcinoma in situ (CIS) of the cervix and breast cancer, respectively. When date of conception plus 1 and 3 years were used as start of follow-up, the rate ratios of CIS of the cervix increased to 0.77 (0.57-1.03) and 0.86 (0.60-1.19), respectively, and the corresponding figures for breast cancer decreased to 0.91 (0.58-1.42) and 0.74 (0.40-1.26). CONCLUSION: Following a relatively short follow-up period, there is little if any increased risk of premenopausal cancer development in women who gave birth after IVF treatment. The women who gave birth after IVF treatment had a decreased incidence of CIS of the cervix and breast cancer, but only the former was statistically significant. However, further studies are necessary to include longer follow-up times.

Place, publisher, year, edition, pages
2007. Vol. 22, no 2, 421-426 p.
Keyword [en]
Adult, Breast Neoplasms/epidemiology, Carcinoma in Situ/epidemiology, Cohort Studies, Female, Fertilization in Vitro, Humans, Incidence, Neoplasms/*epidemiology, Parturition, Pregnancy, Prospective Studies, Risk, Sweden/epidemiology, Uterine Cervical Neoplasms/epidemiology
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-14880DOI: 10.1093/humrep/del411ISI: 000243591200015PubMedID: 17071821OAI: oai:DiVA.org:uu-14880DiVA: diva2:42651
Available from: 2008-01-31 Created: 2008-01-31 Last updated: 2011-08-15Bibliographically approved

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Publisher's full textPubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=17071821&dopt=Citation

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Kristiansson, Per
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