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Genetic susceptibility to retinopathy of prematurity: the evidence from clinical and experimental animal studies
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Ophthalmology.
2007 (English)In: British Journal of Ophthalmology, ISSN 0007-1161, E-ISSN 1468-2079, Vol. 91, no 12, 1704-1708 p.Article, review/survey (Refereed) Published
Abstract [en]

Despite advances in management and treatment, retinopathy of prematurity remains a major cause of childhood blindness. Evidence for a genetic basis for susceptibility to retinopathy of prematurity is examined, including the influences of sex, ethnicity, and ocular pigmentation. The role of polymorphisms is explored in the genes for vascular endothelial growth factor and insulin-like growth factor-1, and of mutations in the Norrie disease gene. Insights into the genetic basis of retinopathy of prematurity provided by the animal model of oxygen induced retinopathy are examined. Evidence for a genetic component for susceptibility to retinopathy of prematurity is strong, although the molecular identity of the gene or genes involved remains uncertain.

Place, publisher, year, edition, pages
2007. Vol. 91, no 12, 1704-1708 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-14886DOI: 10.1136/bjo.2007.117283ISI: 000251032200036PubMedID: 18024814OAI: oai:DiVA.org:uu-14886DiVA: diva2:42657
Available from: 2008-01-31 Created: 2008-01-31 Last updated: 2011-04-06Bibliographically approved

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