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ARHGAP30 is a Wrch-1-interacting protein involved in actin dynamics and cell adhesion
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
2011 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 409, no 1, 96-102 p.Article in journal (Refereed) Published
Abstract [en]

The atypical Rho GTPase Wrch-1 has been proposed roles in cell migration, focal adhesion dissolution, stress fibre break down and tight junction heterogeneity. A screen for Wrch-1 binding-partners identified the novel RhoGAP protein, ARHGAP30, as a Wrch-1 interactor. ARHGAP30 is related to the Cdc42- and Rac1-specific RhoGAP CdGAP, which was likewise found to bind Wrch-1. In contrast to CdGAP, ARHGAP30 serves as a Rac1- and RhoA-specific RhoGAP. Ectopic expression of ARHGAP30 results in membrane blebbing and dissolution of stress-fibres and focal adhesions. Our data suggest roles for ARHGAP30 and CdGAP in regulation of cell adhesion downstream of Wrch-1.

Place, publisher, year, edition, pages
2011. Vol. 409, no 1, 96-102 p.
Keyword [en]
RhoGAP, Wrch-1, Rho, Actin dynamics
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-155603DOI: 10.1016/j.bbrc.2011.04.116ISI: 000291380100016OAI: oai:DiVA.org:uu-155603DiVA: diva2:426843
Available from: 2011-06-27 Created: 2011-06-27 Last updated: 2017-12-11Bibliographically approved

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