uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Insulinoscillationer - en kliniskt betydelsefull rytmik. Diabetesläkemedel bör öka den pulsatila komponenten av insulinfrisättningen: Insulin oscillations -- clinically important rhythm. Antidiabetics should increase the pulsatile component of insulin release
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.
Show others and affiliations
2007 (Swedish)In: Läkartidningen, ISSN 0023-7205, Vol. 104, no 32, 2236-2239 p.Article in journal (Refereed) Published
Abstract [en]

The concentration of circulating insulin oscillates with periods of 3-6 min due to pulsatile release of the hormone from the pancreas. Pulsatile insulin secretion from the individual * cell is driven by slow cycles of Ca2+ elevation due to periodic depolarisation. The Ca2+ oscillations of individual * cells in the islets of Langerhans are entrained into a common rhythm by gap junctional coupling and diffusible factors. Autonomic ganglia coordinate the oscillatory activity of the million islets in the pancreas. ATP binding to purinoceptors causes pronounced Ca2+ spikes that are important for synchronizing the *-cells within and among islets in the pancreas. Inhibition of purinergic P2Y1 receptors selectively abolishes pulsatile insulin release without reducing the average rate of secretion. The insulin oscillations are particularly important for the liver. This organ is also exposed to oscillating levels of glucagon. The latter oscillations are in opposite phase allowing maximal exposure to insulin when the glucagon concentration is at minimum.

Place, publisher, year, edition, pages
2007. Vol. 104, no 32, 2236-2239 p.
National Category
Medical and Health Sciences
Research subject
Medical Cell Biology
Identifiers
URN: urn:nbn:se:uu:diva-14955PubMedID: 17822201OAI: oai:DiVA.org:uu-14955DiVA: diva2:42726
Available from: 2008-11-21 Created: 2008-11-21 Last updated: 2010-04-23Bibliographically approved

Open Access in DiVA

No full text

PubMed

Authority records BETA

Gylfe, Erik

Search in DiVA

By author/editor
Gylfe, Erik
By organisation
Department of Medical Cell Biology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

pubmed
urn-nbn

Altmetric score

pubmed
urn-nbn
Total: 691 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf