No Unexpected Adverse Events and Biochemical Side Effects of Olanzapine as Adjunct Treatment in Adolescent Girls with Eating Disorders
2011 (English)In: Journal of child and adolescent psychopharmacology, ISSN 1044-5463, E-ISSN 1557-8992, Vol. 21, no 3, 221-227 p.Article in journal (Refereed) Published
Objective: Olanzapine has been recently tried to relieve anxiety and hyperactivity in adolescents with eating disorders (EDs). Presently, the side effects of the drug have been evaluated. Method: Forty-seven adolescents with EDs were followed up by repeated blood sampling before, during, and at 3 months after medication with olanzapine. Results: Olanzapine medication was discontinued in three patients because of galactorrhea, seizures, and raised liver enzyme activities, respectively. There was a normalization of glucose, insulin, and lipid profiles during treatment, which was related to weight gain and resumption of menstruations but not to medication. Increases in thyroid-stimulating hormone and prolactin were related to olanzapine medication and comedication with selective serotonine reuptake inhibitors. Three months after discontinuing medication, there were no persisting biochemical effects. Conclusion: The side effects observed were those previously described for olanzapine. Most biochemical changes were related to weight (change) and amenorrhea and not to medication. Placebo-controlled studies are needed to investigate the efficacy of olanzapine in adolescents with EDs.
Place, publisher, year, edition, pages
2011. Vol. 21, no 3, 221-227 p.
IdentifiersURN: urn:nbn:se:uu:diva-155587DOI: 10.1089/cap.2009.0098ISI: 000291466000004OAI: oai:DiVA.org:uu-155587DiVA: diva2:427420