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[11C]Carbon monoxide, a versatile and useful precursor in labelling chemistry for PET-ligand development
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry.
2007 (English)In: Journal of labelled compounds & radiopharmaceuticals, ISSN 0362-4803, E-ISSN 1099-1344, Vol. 50, no 9-10, 794-810 p.Article, review/survey (Refereed) Published
Abstract [en]

In this review the recent progress in the development of suitable precursors for 11C-labelling is discussed. Especially the last few years' advancement of the use of [11C] carbon monoxide as a versatile and useful precursor in labelling chemistry is presented. The development is set in perspective of its potential in applying molecular imaging tools in drug and tracer development.The possibility of exploring small tracer libraries utilizing the microdosing concept is explored.

Place, publisher, year, edition, pages
2007. Vol. 50, no 9-10, 794-810 p.
Keyword [en]
11C-precursors, 11C-carbon monoxide, metal-mediated carbonylations, radical carbonylations, tracer library
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-14972DOI: 10.1002/jlcr.1446ISI: 000250889100007OAI: oai:DiVA.org:uu-14972DiVA: diva2:42743
Available from: 2008-02-01 Created: 2008-02-01 Last updated: 2017-12-11Bibliographically approved

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Långström, Bengt

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