uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Counterbalancing angiogenic regulatory factors control the rate of cancer progression and survival in a stage-specific manner
Show others and affiliations
2011 (English)In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 108, no 24, 9939-9944 p.Article in journal (Refereed) Published
Abstract [en]

Whereas the roles of proangiogenic factors in carcinogenesis are well established, those of endogenous angiogenesis inhibitors (EAIs) remain to be fully elaborated. We investigated the roles of three EAIs during de novo tumorigenesis to further test the angiogenic balance hypothesis, which suggests that blood vessel development in the tumor microenvironment can be governed by a net loss of negative regulators of angiogenesis in addition to the well-established principle of up-regulated angiogenesis inducers. In a mouse model of pancreatic neuroendocrine cancer, administration of endostatin, thrombospondin-1, and tumstatin peptides, as well as deletion of their genes, reveal neoplastic stage-specific effects on angiogenesis, tumor progression, and survival, correlating with endothelial expression of their receptors. Deletion of tumstatin and thrombospondin-1 in mice lacking the p53 tumor suppressor gene leads to increased incidence and reduced latency of angiogenic lymphomas associated with diminished overall survival. The results demonstrate that EAIs are part of a balance mechanism regulating tumor angiogenesis, serving as intrinsic microenvironmental barriers to tumorigenesis.

Place, publisher, year, edition, pages
2011. Vol. 108, no 24, 9939-9944 p.
Keyword [en]
integrins, cell biology
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-155580DOI: 10.1073/pnas.1105041108ISI: 000291594000043OAI: oai:DiVA.org:uu-155580DiVA: diva2:427527
Available from: 2011-06-28 Created: 2011-06-27 Last updated: 2011-06-28Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Rubin, Kristofer
By organisation
Department of Medical Biochemistry and Microbiology
In the same journal
Proceedings of the National Academy of Sciences of the United States of America
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 286 hits
ReferencesLink to record
Permanent link

Direct link