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In vitro imaging techniques in neurodegenerative diseases
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Britt Skogseid)
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry.
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2007 (English)In: Molecular Imaging and Biology, ISSN 1536-1632, E-ISSN 1860-2002, Vol. 9, no 4, 161-175 p.Article in journal (Refereed) Published
Abstract [en]

Neurodegeneration induces various changes in the brain, changes that may be investigated using neuroimaging techniques. The in vivo techniques are useful for the visualization of major changes, and the progressing abnormalities may also be followed longitudinally. However, to study and quantify minor abnormalities, neuroimaging of postmortem brain tissue is used. These in vitro methods are complementary to the in vivo techniques and contribute to the knowledge of pathophysiology and etiology of the neurodegenerative diseases. In vitro radioligand autoradiography has given great insight in the involvement of different neuronal receptor systems in these diseases. Data on the dopamine and cholinergic systems in neurodegeneration are discussed in this review. Also, the amyloid plaques are studied using in vitro radioligand autoradiography. Using one of the newer methods, imaging matrix-assisted laser desorption ionization mass spectrometry, the distribution of a large number of peptides and proteins may be detected in vitro on brain cryosections. In this overview, we describe in vitro imaging techniques in the neurodegenerative diseases as a complement to in vivo positron emission tomography and single photon emission computed tomography imaging.

Place, publisher, year, edition, pages
2007. Vol. 9, no 4, 161-175 p.
Keyword [en]
Alzheimer’s disease, Autoradiography, MALDI mass spectrometry, Neurodegenerative diseases, Parkinson’s disease, PET
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-14995DOI: 10.1007/s11307-007-0088-1ISI: 000247914400002OAI: oai:DiVA.org:uu-14995DiVA: diva2:42766
Available from: 2008-06-24 Created: 2008-06-24 Last updated: 2017-12-11Bibliographically approved

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Långström, BengtLindhe, ÖrjanSvedberg, Marie

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Department of Biochemistry and Organic ChemistryDepartment of Pharmaceutical BiosciencesDepartment of Medical Sciences
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