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Symptom provocation in specific phobia affects the substance P neurokinin-1 receptor systems
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Psychiatry, University hospital.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Radiology, Oncology and Radiation Science, Section of Nuclear Medicine and PET.
Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
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2007 (English)In: Biological Psychiatry, ISSN 0006-3223, E-ISSN 1873-2402, Vol. 61, no 8, 1002-1006 p.Article in journal (Refereed) Published
Abstract [en]

Background: Animal studies demonstrate that stress and negative affect enhance the release of the neuropeptide substance P (SP), which binds to the neurokinin 1 (NK1) receptor. This positron emission tomography (PET) study evaluated how the activity in the SP-NK1 receptor system in the amygdala was affected by fear provocation in subjects with specific phobia. Methods: Sixteen adult women with DSM-IV-defined specific phobia for either snakes or spiders but not both viewed pictures of feared and non-feared animals while being PET-scanned for 60 min with the highly specific NK1 receptor antagonist [11C]GR205171 as the labeled PET tracer. Results: The uptake of the labeled NK1 receptor antagonist was significantly reduced in the right amygdala during phobic stimulation. In the left amygdala no significant differences were found between phobic and non-phobic conditions. There was a negative correlation in the right, but not left, amygdala between subjective anxiety ratings and NK1 tracer binding. Conclusions: Fear provocation affects the SP-NK1 receptor system in the right amygdala. This reflects reduced NK1 receptor availability during fear and could mirror an increased release of endogenous substance P.

Place, publisher, year, edition, pages
2007. Vol. 61, no 8, 1002-1006 p.
Keyword [en]
Anxiety, brain, NK1-receptor, PET, specific phobia, substance P
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-15000DOI: 10.1016/j.biopsych.2006.07.003ISI: 000245636400012PubMedID: 16950220OAI: oai:DiVA.org:uu-15000DiVA: diva2:42771
Available from: 2008-02-01 Created: 2008-02-01 Last updated: 2017-12-11Bibliographically approved

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Appel, LieuweFrans, ÖrjanLångström, Bengt

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Appel, LieuweFrans, ÖrjanLångström, Bengt
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Department of NeuroscienceDepartment of Psychiatry, University hospitalSection of Nuclear Medicine and PETDepartment of PsychologyDepartment of Biochemistry and Organic Chemistry
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