uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Comparative genomic analysis of three Leishmania species that cause diverse human disease.
Show others and affiliations
2007 (English)In: Nature Genetics, ISSN 1061-4036, Vol. 39, no 7, 839-847 p.Article in journal (Refereed) Published
Abstract [en]

Leishmania parasites cause a broad spectrum of clinical disease. Here we report the sequencing of the genomes of two species of Leishmania: Leishmania infantum and Leishmania braziliensis. The comparison of these sequences with the published genome of Leishmania major reveals marked conservation of synteny and identifies only 200 genes with a differential distribution between the three species. L. braziliensis, contrary to Leishmania species examined so far, possesses components of a putative RNA-mediated interference pathway, telomere-associated transposable elements and spliced leader–associated SLACS retrotransposons. We show that pseudogene formation and gene loss are the principal forces shaping the different genomes. Genes that are differentially distributed between the species encode proteins implicated in host-pathogen interactions and parasite survival in the macrophage.

Place, publisher, year, edition, pages
2007. Vol. 39, no 7, 839-847 p.
Keyword [en]
Amino Acid Sequence, Animals, Genome, Genomics, Humans, Leishmania/*genetics, Leishmania braziliensis/genetics, Leishmania infantum/genetics, Leishmania major/genetics, Leishmaniasis/*parasitology, Leishmaniasis; Cutaneous/parasitology, Leishmaniasis; Visceral/parasitology, Molecular Sequence Data
National Category
Biological Sciences
URN: urn:nbn:se:uu:diva-15051DOI: 10.1038/ng2053PubMedID: 17572675OAI: oai:DiVA.org:uu-15051DiVA: diva2:42822
Available from: 2008-02-04 Created: 2008-02-04 Last updated: 2010-02-04Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=17572675&dopt=Citation

Search in DiVA

By author/editor
Baldauf, Sandra L
By organisation
Systematic Botany
In the same journal
Nature Genetics
Biological Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 191 hits
ReferencesLink to record
Permanent link

Direct link