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Cerebrospinal fluid protein reactions during non-neurological surgery
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Thoracic Surgery. (Thorac Surgery)
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2007 (English)In: Acta Neurologica Scandinavica, ISSN 0001-6314, E-ISSN 1600-0404, Vol. 115, no 4, 254-259 p.Article in journal (Refereed) Published
Abstract [en]

Objective - To study changes in cerebrospinal fluid (CSF) protein markers of blood-CSF barrier integrity and immunological reactions during surgical stress. Subjects and methods - Thirty-five patients without neurological or psychiatric disorders undergoing knee replacements had CSF and serum samples drawn from spinal and arterial catheters before, 3 h after and the morning after surgery. Results - Serum albumin decreased during surgery and CSF albumin decreased during and after surgery, and, as a consequence, the CSF/serum albumin ratio decreased significantly during the study period, especially after the intervention. In contrast, CSF concentrations of beta-2-microglobuline (β2M) increased significantly during surgery and remained high. The CSF general marker beta-trace protein (βTP) remained unchanged. Conclusions - Central nervous system protein reactions to a non-neurological surgical intervention include sharply decreased permeability of albumin into the CSF and signs of intrathecal inflammatory activity.

Place, publisher, year, edition, pages
2007. Vol. 115, no 4, 254-259 p.
Keyword [en]
Albumin, Beta-2-microglobuline, Blood-brain barrier, Cerebrospinal fluid, Inflammation, Spinal anaesthesia, Stress
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-15067DOI: 10.1111/j.1600-0404.2006.00741.xISI: 000245054800006PubMedID: 17376123OAI: oai:DiVA.org:uu-15067DiVA: diva2:42838
Available from: 2008-02-04 Created: 2008-02-04 Last updated: 2011-02-09Bibliographically approved

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