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Preservation of Antimicrobial Properties of Complement Peptide C3a, from Invertebrates to Humans
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
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2007 (English)In: Journal of Biological Chemistry, ISSN 0021-9258, E-ISSN 1083-351X, Vol. 282, no 4, 2520-2528 p.Article in journal (Refereed) Published
Abstract [en]

The human anaphylatoxin peptide C3a, generated during complement activation, exerts antimicrobial effects. Phylogenetic analysis, sequence analyses, and structural modeling studies paired with antimicrobial assays of peptides from known C3a sequences showed that, in particular in vertebrate C3a, crucial structural determinants governing antimicrobial activity have been conserved during the evolution of C3a. Thus, regions of the ancient C3a from Carcinoscorpius rotundicauda as well as corresponding parts of human C3a exhibited helical structures upon binding to bacterial lipopolysaccharide permeabilized liposomes and were antimicrobial against Gram-negative and Gram-positive bacteria. Human C3a and C4a (but not C5a) were antimicrobial, in concert with the separate evolutionary development of the chemotactic C5a. Thus, the results demonstrate that, notwithstanding a significant sequence variation, functional and structural constraints imposed on C3a during evolution have preserved critical properties governing antimicrobial activity.

Place, publisher, year, edition, pages
2007. Vol. 282, no 4, 2520-2528 p.
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Pharmaceutical Sciences Medical and Health Sciences Natural Sciences
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URN: urn:nbn:se:uu:diva-15071DOI: 10.1074/jbc.M607848200ISI: 000243593200044OAI: oai:DiVA.org:uu-15071DiVA: diva2:42842
Available from: 2008-02-04 Created: 2008-02-04 Last updated: 2017-12-11Bibliographically approved

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Malmsten, Martin

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