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Tolterodine and imipramine in refractory enuresis; a placebo-controlled crossover study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health.ORCID iD: 0000-0002-4590-4957
2008 (English)In: Pediatric nephrology (Berlin, West), ISSN 0931-041X, E-ISSN 1432-198X, Vol. 23, no 2, 263-267 p.Article in journal (Refereed) Published
Abstract [en]

The anticholinergic drug tolterodine has been suggested to be useful in therapy-resistant enuresis. Imipramine has a proven efficiency in unselected enuretic patients, but due to its side-effect profile it is only indicated, if at all, in therapy-resistant cases. We therefore compared these two drugs to placebo. Twenty-seven children with enuresis resistant to the alarm and to desmopressin in monotherapy were given placebo, tolterodine 1-2 mg, and imipramine 25-50 mg at bedtime for 5 weeks each in a randomised, double-blind, crossover fashion. The number of wet nights during the last 2 weeks of each treatment period was compared. One patient became spontaneously dry at the start of the study, and one dropped out due to side effects. Among the remaining 25 children, the number of wet nights during placebo, tolterodine and imipramine treatment were 11.0 +/- 3.9, 10.4 +/- 3.9 and 7.8 +/- 5.1, respectively (p < 0.001). Imipramine was significantly better than both placebo (p=0.001) and tolterodine (p=0.006). Nine children experienced side effects on imipramine and one on tolterodine (p=0.001). This is the first study on anticholinergics or imipramine in children with therapy-resistant enuresis. Tolterodine, in monotherapy, had no proven effect. Imipramine was better than placebo, but side effects were common.

Place, publisher, year, edition, pages
2008. Vol. 23, no 2, 263-267 p.
Keyword [en]
enuresis, imipramine, tolterodine, anticholinergics, antidepressants
National Category
Pediatrics
Identifiers
URN: urn:nbn:se:uu:diva-15106DOI: 10.1007/s00467-007-0662-4ISI: 000252298600012PubMedID: 18004596OAI: oai:DiVA.org:uu-15106DiVA: diva2:42877
Available from: 2008-02-05 Created: 2008-02-05 Last updated: 2017-12-11

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Nevéus, Tryggve

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