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Computational analysis of transcriptional regulation in proximal versus distal normal colon
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Biology Education Centre.
2011 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Factors involved in transcriptional regulation in the normal colon were investigated computationally. Genes differentially expressed between distal and proximal colon were identified and their promoter structures were analysed for presence of TATA-boxes, CpG islands and transcription factor binding sites. The CpG methylation status of the genes were experimentally verified in colon cancer cell lines and compared between the two groups ofdifferentially expressed genes. A difference in methylation frequency in colon cancer celllines was detected between genes up-regulated and down-regulated in normal proximal colon.

Place, publisher, year, edition, pages
2011. , 46 p.
Keyword [en]
Colon, computational alalysis, Transcriptional regulation, Microarray analysis, gene expression, network analysis
URN: urn:nbn:se:uu:diva-155889OAI: oai:DiVA.org:uu-155889DiVA: diva2:429115
Educational program
Molecular Biotechnology Engineering Programme
Available from: 2011-07-05 Created: 2011-07-03 Last updated: 2011-07-05Bibliographically approved

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