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Prognostic significance of matrix metalloproteinase-20 overexpression in laryngeal squamous cell carcinoma
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2011 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 131, no 7, 769-773 p.Article in journal (Refereed) Published
Abstract [en]

Conclusion: Matrix metalloproteinase (MMP)-20 is overexpressed in laryngeal squamous cell carcinoma (LSCC) compared with the adjacent normal laryngeal epithelium and MMP-20 plays a role in lymph node metastasis. Overexpression of MMP-20 may be used as a significant prognostic factor for lymph node metastasis. All the findings indicate that MMP-20 may play a role in the initiation and progression of LSCC. Objective: The MMPs are a gene family of zinc-dependent endopeptidases that have been implicated in tumor invasion and metastasis, and MMP-20 is a new member of the MMP family. The purpose of this study was to investigate whether MMP-20 is overexpressed in human LSCC and, if so, the significance of its overexpression in relation to clinical parameters. Methods: We analyzed 33 cases of LSCC with RT-PCR and 73 cases of LSCC with immunohistochemistry compared with normal laryngeal epithelium. Results: We found that MMP-20 is overexpresssed in LSCC compared with the adjacent normal laryngeal epithelium.

Place, publisher, year, edition, pages
2011. Vol. 131, no 7, 769-773 p.
Keyword [en]
Enamelysin, prognostic evaluation
National Category
Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-156016DOI: 10.3109/00016489.2011.560186ISI: 000291677100012OAI: oai:DiVA.org:uu-156016DiVA: diva2:429726
Available from: 2011-07-05 Created: 2011-07-05 Last updated: 2017-12-11Bibliographically approved

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Anniko, Matti

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Otolaryngology and Head and Neck Surgery
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