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Low levels of apolipoprotein A-I and HDL are associated with risk of prostate cancer in the Swedish AMORIS study
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2011 (English)In: Cancer Causes and Control, ISSN 0957-5243, E-ISSN 1573-7225, Vol. 22, no 7, 1011-1019 p.Article in journal (Refereed) Published
Abstract [en]


A detailed analysis of lipid profiles, using apolipoproteins, has not yet been conducted for prostate cancer (PCa). Since several etiological pathways have been proposed for PCa and lipids, we aimed to study this in a large Swedish cohort with 1,469 primary prostate cancers.


A cohort (n = 69,735) of all men aged 35 years or older, whose levels of triglycerides (TG) (mmol/L), total cholesterol (mmol/L), glucose (mmol/L), LDL (mmol/L), HDL (mmol/L), apoB (g/L), and apoA-I (g/L) were measured at baseline, was selected from the Apolipoprotein MOrtality RISk (AMORIS) database. About 2,008 men developed PCa. Multivariate Cox proportional hazard models were used to analyze associations between lipid components and PCa.


ApoA-I and HDL were inversely associated with PCa risk (e.g., HR for HDL: 0.93 (95% CI: 0.81-1.07), 0.88 (0.76-1.01), 0.81 (0.70-0.94), for second, third, and fourth quartiles compared with the first quartile; with p for trend: 0.004; HR for apoA-I: 1.00 (0.88-1.13), 0.93 (0.82-1.05), 0.88 (0.77-0.99),), for second, third, and fourth quartiles compared with the first quartile; with p for trend: 0.022). ApoB, LDL, and non-HDL were not associated with PCa risk.


Our results show that low HDL and ApoA-I as well as increased lipid ratios are related to increased PCa risk. Experimental studies are required to tease out the underlying biological mechanisms linking these lipid components to PCa.

Place, publisher, year, edition, pages
2011. Vol. 22, no 7, 1011-1019 p.
Keyword [en]
Prostate cancer, Hypercholesterolemia, Hypertriglyceridemia, Apolipoproteins, Lipids, Cholesterol
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-156004DOI: 10.1007/s10552-011-9774-zISI: 000291742700008PubMedID: 21562751OAI: oai:DiVA.org:uu-156004DiVA: diva2:429845
Available from: 2011-07-06 Created: 2011-07-05 Last updated: 2012-05-08Bibliographically approved

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Endocrine Surgery
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